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SPYRE THERAPEUTICS INC

88.14

-2.2250-2.46%

Volume:796.14K

Turnover:70.32M

Market Cap:7.77B

PE:-43.85

High:90.97

Open:89.15

Low:87.05

Close:90.36

52wk High:110.18

52wk Low:14.51

Shares:88.17M

Float Shares:80.98M

Volume Ratio:0.84

T/O Rate:0.98%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.0100

EPS(LYR):-1.9755

ROE:-22.98%

ROA:-19.81%

PB:8.14

PE(LYR):-44.61

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Overview Company News Filings

Analysts Offer Insights on Healthcare Companies: Revolution Medicines (RVMD) and Spyre Therapeutics (SYRE)

U.S. Research Roundup-CrowdStrike, Nvidia, Macerich

Top Midday Decliners

MT Newswires Live

Spyre Therapeutics falls -13.2%

Spyre Therapeutics Down over 12%, on Pace for Largest Percent Decrease Since June 2024

U.S. Stocks on the MOVE-Semtech, Donaldson, Meta

Spyre Therapeutics (SYRE) Gets a Buy from LifeSci Capital

Analysts Offer Insights on Healthcare Companies: Solventum Corporation (SOLV), Argenx Se (ARGX) and Spyre Therapeutics (SYRE)

Spyre Therapeutics Reports Phase 2 Skyway RA Data for Spy072 Shows Statistically Significant Benefit vs Placebo

Spyre Therapeutics Shares Down 12.4% Premarket After Co's Experimental Drug Fails to Meet Threshold for Monotherapy Development in Rheumatoid Arthritis

THOMSON REUTERS

Spyre Therapeutics Inc : Btig Cuts Target Price to $121 from $132

THOMSON REUTERS

Stocks to Watch: Intuit, Spyre Therapeutics, Zoom Communications, nCino

Spyre Therapeutics Stock (SYRE) Tumbles 14% in After-Hours – Here’s What Spooked Investors

Spyre Therapeutics Won't Prioritize Rheumatoid Arthritis Monotherapy After Trial

Spyre Therapeutics announces results from RA sub-study of SKYWAY basket trial

Spyre Therapeutics Announces Topline Results from the Rheumatoid Arthritis Sub-Study of the Skyway Phase 2 Trial of Spy072

THOMSON REUTERS

Spyre Therapeutics - Spy072 Well Tolerated with Adverse Event Rates Comparable to Placebo

THOMSON REUTERS

Spyre Therapeutics Inc: Spy072 in Combination with Il17-a/F in Hidradenitis Suppurativa (Hs) in Late 2027 or Early 2028

THOMSON REUTERS

Spyre Therapeutics - Topline Data for Spy072 in Psa and Axspa Expected Q4 2026

THOMSON REUTERS

Spyre Therapeutics Inc - Magnitude of Effect Did not Meet Company's Target to Prioritize Monotherapy Development of Spy072 in Rheumatoid Arthritis

THOMSON REUTERS

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halt of its monotherapy RA program.Shares dropped 14% as intraday trading volume rose to over 1.96 million from a daily average of about 1.25 million.Price: 32.20, Change: -7.14, Percent Change: -18.15","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4139","ELMD","SYRE","GRML","BK4082","LFSC"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2662474530","title":"Spyre Therapeutics falls 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Published first on TheFly – the ultimate source for real-time, market-moving breaki...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/spyre-therapeutics-falls-13-2-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/spyre-therapeutics-falls-13-2-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LFSC","BK4139","BK4539","SYRE","BK4007","LENZ"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2662104247","title":"Spyre Therapeutics Down over 12%, on Pace for Largest Percent Decrease Since June 2024","url":"https://stock-news.laohu8.com/highlight/detail?id=2662104247","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2662104247?lang=en_us&edition=fundamental","pubTime":"2026-08-26 22:35","pubTimestamp":1787754900,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics, Inc  is currently at $94.12, down $13.24 or 12.33%--Would be lowest close since July 16, 2026, when it closed at $94.12--On pace for largest percent decrease since June 17, 2024, when it fell 19.3%--Snaps a two day winning streak--Down 4.28% month-to-date; on pace for worst month since April 2025, when it fell 5.61%--Up 187.3% year-to-date--Down 68.6% from its all-time closing high of $299.75 on April 8, 2016--Up 449.12% from 52 weeks ago , when it closed at $17.14--Down 13.59% from its 52-week closing high of $108.92 on Aug. 19, 2026--Up 535.09% from its 52-week closing low of $14.82 on Sept. 16, 2025--Traded as low as $90.60; lowest intraday level since July 7, 2026, when it hit $86.60--Down 15.61% at today's intraday low; largest intraday percent decrease since June 24, 2026, when it fell as much as 15.87%All data as of 10:32:24 AM ETSource: Dow Jones Market Data, FactSet","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","BK4007","BK4539","LENZ","SYRE","LFSC"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2662171137","title":"U.S. Stocks on the MOVE-Semtech, Donaldson, 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The company may also accept short-term trade-offs in its business as it looks to boost TurboTax customers, its CFO told The Wall Street Journal. Shares fell 9.8% to $322.57 in after-hours trading on Tuesday.Spyre Therapeutics said it will not prioritize developing one of its drug candidates as a monotherapy for rheumatoid arthritis after results from a trial missed its internal targets. The stock slid 11% to $95.09 after the bell.Zoom Communications issued guidance for third-quarter adjusted earnings per share that missed Wall Street expectations. Shares were down 3.9% at $97.00.NCino projected third-quarter revenue in a range with a midpoint below analyst expectations. 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