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Spruce Biosciences, Inc.

55.60

-3.3700-5.71%

Volume:58.13K

Turnover:3.28M

Market Cap:159.80M

PE:-1.45

High:58.05

Open:58.01

Low:55.34

Close:58.97

52wk High:240.00

52wk Low:7.26

Shares:2.87M

Float Shares:2.29M

Volume Ratio:0.72

T/O Rate:2.54%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-38.4300

EPS(LYR):-50.8298

ROE:-105.98%

ROA:-40.03%

PB:1.91

PE(LYR):-1.09

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Overview Company News Filings

Spruce Biosciences initiated with a Buy at JonesResearch

Spruce says long-term TA-ERT data presented at MPS Symposium

Spruce Biosciences reports six-year tralesinidase alfa data showing sustained biomarker reductions, stabilized cognition in MPS IIIB

Spruce Biosciences Announces Long-Term Tralesinidase Alfa Enzyme Replacement Therapy Data in Sanfilippo Syndrome Type B (Mps Iiib) Presented at the 18TH International Mps Symposium

THOMSON REUTERS

Spruce Biosciences Is Maintained at Buy by HC Wainwright & Co.

Spruce Biosciences, Inc : H.c. Wainwright Cuts Target Price to $150 From $200

THOMSON REUTERS

Spruce Biosciences Announces Data Presentation At The 18Th International MPS Symposium

Spruce Biosciences to present long-term tralesinidase alfa data in Sanfilippo syndrome Type B at International MPS Symposium

Spruce Biosciences Announces Data Presentation at the 18TH International Mps Symposium

THOMSON REUTERS

Spruce Biosciences to present at Jefferies Global Healthcare Conference

Analysts’ Top Healthcare Picks: Spruce Biosciences (SPRB), CG Oncology, Inc. (CGON)

Spruce Biosciences Stockholders Approve Directors and Annual Say-on-Pay

Spruce Biosciences shareholders elect Class III directors at annual meeting

Spruce Biosciences, Inc : Leerink Partners Cuts Target Price to $120 From $140

THOMSON REUTERS

Spruce Biosciences Is Maintained at Market Outperform by Citizens

Spruce Biosciences price target lowered to $150 from $170 at Citizens

Spruce Biosciences reports Q1 EPS ($8.94), consensus ($6.11)

Spruce Biosciences, Inc reports results for the quarter ended March 31 - Earnings Summary

Spruce Biosciences Q1 FY26 net loss narrows to $12.27 million; R&D expenses fall to $7.58 million

Spruce Biosciences Reports First Quarter 2026 Financial Results and Provides Corporate Updates

THOMSON REUTERS

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Spruce Biosciences reported long-term data for tralesinidase alfa enzyme replacement therapy in Sanfilippo syndrome type B, presented June 4-7, 2026.Results included data previously presented at the 22nd Annual WORLD Symposium, extending follow-up to as long as six years.Treatment was associated with sustained disease-biomarker improvement, with cognitive function and daily functioning preserved versus declines in untreated natural history patients.Imaging and organ assessments were consistent with stabilization of disease-related changes, supporting a potential disease-modifying profile.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financia","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260608:nNDLC4gpf:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2642431354","title":"Spruce Biosciences Announces Long-Term Tralesinidase Alfa Enzyme Replacement Therapy Data in Sanfilippo Syndrome Type B (Mps Iiib) Presented at the 18TH International Mps Symposium","url":"https://stock-news.laohu8.com/highlight/detail?id=2642431354","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2642431354?lang=en_us&edition=fundamental","pubTime":"2026-06-09 04:05","pubTimestamp":1780949100,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260608:nTUA3BHBKF:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640956880","title":"Spruce Biosciences Is Maintained at Buy by HC Wainwright & Co.","url":"https://stock-news.laohu8.com/highlight/detail?id=2640956880","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640956880?lang=en_us&edition=fundamental","pubTime":"2026-06-01 19:12","pubTimestamp":1780312320,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SPRB/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  June 01, 2026 07:12 ET (11:12 GMT)","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640495810","title":"Spruce Biosciences, Inc : H.c. 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email: reutersinvestor.briefs@thomsonreuters.com))  Source Date/Time = 28-MAY-202620:05:00.437 GMT","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260528:nRSDbwpy1x:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"conferences","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2639861680","title":"Spruce Biosciences to present long-term tralesinidase alfa data in Sanfilippo syndrome Type B at International MPS Symposium","url":"https://stock-news.laohu8.com/highlight/detail?id=2639861680","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2639861680?lang=en_us&edition=fundamental","pubTime":"2026-05-29 04:09","pubTimestamp":1779998976,"startTime":"0","endTime":"0","summary":"Spruce Biosciences flagged long-term data for tralesinidase alfa in Sanfilippo syndrome type B for presentation on June 6, 2026.Results will be presented in Florence at the 18th International MPS & Related Lysosomal Diseases Symposium.Study readout points to sustained disease-biomarker reduction with stabilization of cognition and brain gray matter volume over extended treatment.Update keeps the program positioned as a potential late-stage therapy option in a rare neurologic disorder with limited treatment choices.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260528:nNDL5JKhxh:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2639615762","title":"Spruce Biosciences Announces Data Presentation at the 18TH International Mps Symposium","url":"https://stock-news.laohu8.com/highlight/detail?id=2639615762","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2639615762?lang=en_us&edition=fundamental","pubTime":"2026-05-29 04:05","pubTimestamp":1779998701,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260528:nTUAC67LFJ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2638263596","title":"Spruce Biosciences to present at Jefferies Global Healthcare Conference","url":"https://stock-news.laohu8.com/highlight/detail?id=2638263596","media":"Reuters","labels":["conferences"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2638263596?lang=en_us&edition=fundamental","pubTime":"2026-05-28 04:06","pubTimestamp":1779912398,"startTime":"0","endTime":"0","summary":"Spruce Biosciences management to present at the Jefferies Global Healthcare Conference on June 4, 2026 at 11:05 a.m. ET in New York.Company to hold one-on-one meetings at the BIO International Convention on June 24-25 in San Diego.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260527:nNDL8JKCFT:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"conferences","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2638768837","title":"Analysts’ Top Healthcare Picks: Spruce Biosciences (SPRB), CG Oncology, Inc. 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Spruce Biosciences, Inc. held its 2026 Annual Meeting of Stockholders on May 21, 2026, i...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/spruce-biosciences-stockholders-approve-directors-and-annual-say-on-pay?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/spruce-biosciences-stockholders-approve-directors-and-annual-say-on-pay?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2638540373","title":"Spruce Biosciences shareholders elect Class III directors at annual meeting","url":"https://stock-news.laohu8.com/highlight/detail?id=2638540373","media":"Reuters","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2638540373?lang=en_us&edition=fundamental","pubTime":"2026-05-27 04:03","pubTimestamp":1779825823,"startTime":"0","endTime":"0","summary":"Spruce Biosciences held its annual shareholder meeting on May 21, 2026.Shareholders selected Michael Grey, Camilla V. Simpson, and Javier Szwarcberg to serve as Class III directors through the 2029 annual meeting.BDO USA, P.C. was ratified as independent registered public accounting firm for the fiscal year ending Dec. 31, 2026.Shareholders backed an annual advisory vote on executive pay frequency, setting the company’s expected cadence through the next required frequency vote by 2032.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Spruce Biosciences Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange C","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260526:nNDL6z0xkS:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2635746754","title":"Spruce Biosciences, Inc : Leerink Partners Cuts Target Price to $120 From $140","url":"https://stock-news.laohu8.com/highlight/detail?id=2635746754","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2635746754?lang=en_us&edition=fundamental","pubTime":"2026-05-14 23:04","pubTimestamp":1778771053,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260514:nFWN41R1EV:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["SPRB","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2635745125","title":"Spruce Biosciences Is Maintained at Market Outperform by Citizens","url":"https://stock-news.laohu8.com/highlight/detail?id=2635745125","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2635745125?lang=en_us&edition=fundamental","pubTime":"2026-05-14 22:28","pubTimestamp":1778768880,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SPRB/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  May 14, 2026 10:28 ET (14:28 GMT)","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2635713325","title":"Spruce Biosciences price target lowered to $150 from $170 at Citizens","url":"https://stock-news.laohu8.com/highlight/detail?id=2635713325","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2635713325?lang=en_us&edition=fundamental","pubTime":"2026-05-14 17:58","pubTimestamp":1778752685,"startTime":"0","endTime":"0","summary":"Citizens lowered the firm’s price target on Spruce Biosciences (SPRB) to $150 from $170 and keeps an Outperform rating on the shares. Spruce remain...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/spruce-biosciences-price-target-lowered-to-150-from-170-at-citizens-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/spruce-biosciences-price-target-lowered-to-150-from-170-at-citizens-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2635317387","title":"Spruce Biosciences reports Q1 EPS ($8.94), consensus ($6.11)","url":"https://stock-news.laohu8.com/highlight/detail?id=2635317387","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2635317387?lang=en_us&edition=fundamental","pubTime":"2026-05-14 00:56","pubTimestamp":1778691410,"startTime":"0","endTime":"0","summary":"“We are very pleased with the meaningful progress we continue to make in advancing TA-ERT toward our planned biologics license application submissi...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/spruce-biosciences-reports-q1-eps-8-94-consensus-6-11-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/spruce-biosciences-reports-q1-eps-8-94-consensus-6-11-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2635736679","title":"Spruce Biosciences, Inc reports results for the quarter ended March 31 - Earnings Summary","url":"https://stock-news.laohu8.com/highlight/detail?id=2635736679","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2635736679?lang=en_us&edition=fundamental","pubTime":"2026-05-13 23:21","pubTimestamp":1778685676,"startTime":"0","endTime":"0","summary":"Spruce Biosciences, Inc reports results for the quarter ended March 31 - Earnings SummarySpruce Biosciences, Inc SPRB.OQ reported a quarterly adjusted loss of $8.94 per share for the quarter ended Mar","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260513:nL8N41Q27E:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2635178438","title":"Spruce Biosciences Q1 FY26 net loss narrows to $12.27 million; R&D expenses fall to $7.58 million","url":"https://stock-news.laohu8.com/highlight/detail?id=2635178438","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2635178438?lang=en_us&edition=fundamental","pubTime":"2026-05-13 20:01","pubTimestamp":1778673698,"startTime":"0","endTime":"0","summary":"Spruce Biosciences posted a first-quarter net loss of $12.27 million, narrowing from $14.04 million a year earlier; loss per share improved to $8.94 from $23.95.R&D expense fell to $7.58 million from $10.84 million, due to $5.7 million of one-time product acquisition costs tied to SPR202 and $1.9 million from discontinuing the tildacerfont congenital adrenal hyperplasia program.G&A expense rose to $4.41 million from $3.66 million, while total operating expense declined to $11.99 million from $14.49 million.Cash and cash equivalents totaled $54.08 million at March 31, rising from $48.91 million at year-end; cash was about $107.3 million as of April 30 following a $69 million public offering and a $50 million term loan facility with Avenue Capital.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260513:nNDLtCPHN:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SPRB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2635781023","title":"Spruce Biosciences Reports First Quarter 2026 Financial Results and Provides Corporate Updates","url":"https://stock-news.laohu8.com/highlight/detail?id=2635781023","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2635781023?lang=en_us&edition=fundamental","pubTime":"2026-05-13 20:00","pubTimestamp":1778673607,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260513:nTUA8T9TYR:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","SPRB"],"isVideo":false,"video":null,"gpt_icon":0}],"pageSize":20,"totalPage":5,"pageCount":3,"totalSize":100,"code":"91000000","status":"200"}]}}